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外体作为瘤免疫通信的关键媒介:对免疫疗法和液体活检的影响

Menglin Wei^1,2, Dongli Wang^1,2, Wenrong Xu^1,2

¹Aoyang Institute of Cancer, Center of Clinical Laboratory, Affiliated Aoyang Hospital of Jiangsu University, Suzhou, Jiangsu, 215600, People's Republic of China.

International journal of nanomedicine

|March 3, 2026

概括

外基因组是参与细胞通信的微小囊泡,在癌症免疫力中起着双重作用,可以抑制或增强抗瘤反应. 研究探讨了它们在新型癌症免疫疗法和诊断方面的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

外体是分泌的囊泡,调解细胞间的通信.
它们在癌症进展和瘤免疫微环境 (TME) 中的作用是复杂和上下文依赖的.
外体细胞可以促进免疫抑制或增强抗瘤免疫力.

研究的目的:

审查外体在瘤免疫生物学中的多方面的作用.
综合近期基于外体的免疫疗法的进展,包括与免疫检查点封锁和采用细胞疗法的组合.
批判性地评估用于液体活检和生物标志物开发的外体隔离和表征的新技术.

主要方法:

对癌症中的外体细胞功能进行全面的文献综述.
对基于外体细胞的免疫治疗策略的数据的综合.
对外体隔离和分析新兴技术的评估.

主要成果:

外基因组在癌症免疫中表现出双模功能,影响免疫抑制和抗瘤反应.
基于外体的疗法显示出与现有的癌症治疗具有协同作用的潜力.
先进的外体隔离和表征技术增强了液体活检和生物标志物发现.

结论:

外体是瘤免疫微环境中的关键调解者,具有显著的治疗和诊断潜力.
以外体为中心的策略在精密免疫瘤学中是一个有前途的前沿.
本综述强调了外体对个性化癌症护理和克服治疗耐药性的变革性影响.

关键词:

生物标志物生物标志物癌症免疫疗法免疫疗法在外基因组中,外基因组是外基因组.液体活检活检液体活检瘤免疫的微环境

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