评估人体指数及其主要组成部分与2型糖尿病的关联,在一个横截面研究中
Sara Javadi1, Shideh Rafati2,3, Sara Binaei3
1Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal of diabetes and metabolic disorders
|March 3, 2026
概括
身体脂肪分布,特别是腰部和部的比例 (WHR),是2型糖尿病 (T2DM) 风险的更好的指标,而不是伊朗成年人的体重指数 (BMI). 性别特定的评估对于准确的T2DM风险评估至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个显著且不断升级的全球健康挑战,伊朗的流行率显著.
- 与整体体重测量相比,身体脂肪分布模式提供了对T2DM风险的更细致的评估.
研究的目的:
- 调查各种人体指数与伊朗成年人群中T2DM发展风险之间的关联.
- 评估不同人体测量方法的有效性,包括从中衍生的主要成分,用于预测T2DM风险.
- 确定T2DM查关键人体指数的最佳,性别特定的切线点.
主要方法:
- 一项涉及3,916名伊朗成年人 (年龄在35-70岁之间) 的横截面研究,来自班达雷-孔格非传染性疾病 (BKNCD) 队列.
- 主要组件分析 (PCA) 应用于九个人体测量 (ABSI,BRI,BAI,WHTR,WHR,腰围,BMI,部周围,手腕比例).
- 使用后勤回归分析和接收器操作特征 (ROC) 曲线来评估关联并确定诊断准确性.
主要成果:
- 18.7%的参与者患有T2DM. 腰部至部比 (WHR) 在男性 (OR=1.61) 和女性 (OR=1.94) 两种类型的T2DM风险中表现出最强烈的关联,显示出中度的区分性表现 (AUC:男性0.66,女性0.72).
- 中央脂肪指数,特别是WHR,与T2DM风险的关联比BMI更强.
- 观察到性别特异性差异;WHR在女性 (PC2) 中尤为显著,而腰围在男性中显示出强烈的关联和高灵敏度但低特异性.
结论:
- 中央脂肪指数,特别是WHR,在确定被研究的伊朗人口中的T2DM风险方面比BMI更有价值,尽管诊断准确度中等.
- 最佳的人类指数及其对T2DM风险评估的解释在性别之间有所不同.
- 推实施性别特定的临床评估,以改善T2DM风险分层.
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