在通过体外受精怀孕的双胞胎中,先进的父母年龄和周产期风险
Jing Lin1, Tianying Yang2, Fenglu Wu3
1Center for Reproductive Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
Andrology
|March 3, 2026
概括
先进的父母年龄与出生体重不一致的风险更高,并且在双胞胎中对于妊娠年龄小. 这项研究强调了父母年龄作为双胞胎周产期结局的一个因素.
科学领域:
- 生殖医学 生殖医学
- 围产期流行病学 围产期流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 由于辅助生殖技术,父母的晚年越来越普遍.
- 父母年龄对双胞胎妊娠结果的影响需要进一步研究.
研究的目的:
- 评估通过体外受精 (IVF) 怀孕的双胞胎怀孕中父母的晚年 (≥35岁) 和围产期风险之间的关联.
主要方法:
- 分析了来自试管婴儿周期的7514对双胞胎,分别和组合地检查了母亲和父亲的晚年.
- 后勤回归模型计算了几率比率 (ORs) 对于诸如出生体重异常和妊娠年龄小 (SGA) 等结果.
- 使用分类变量和受限制的立方线,探索了剂量反应和值效应.
主要成果:
- 先进的父亲年龄 (≥35) 增加了出生体重不一致的几率 (aOR,1.20),剂量反应趋势从30岁开始,值在37岁.
- 晚期母亲年龄 (≥35) 增加了SGA的几率 (aOR,1.21),趋势从30岁开始,值在30岁.
- 结合先进的父母年龄 (两者≥35) 显著增加了出生体重异常 (aOR, 1.37) 和SGA (aOR, 1.30) 的风险.
结论:
- 高龄的父母年龄是对双胞胎产前不良结果的重要风险因素,特别是出生体重异常和SGA.
- 这些发现强调了在管理双胞胎怀孕时考虑父母年龄的重要性,特别是那些通过试管婴儿受孕的怀孕.
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