相关实验视频

Updated: Jun 11, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

儿童肺移植急性排斥的危险因素及其对移植失败的影响

Sophie Li¹, Spoorthi Kamepalli¹, David Moreno McNeill²

¹Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA.

Pediatric pulmonology

|March 3, 2026

概括

循环氨酸治疗,长时间的缺血和HLA-A不匹配增加了儿科肺移植中急性排斥风险. 西班牙裔种族和抗红细胞球蛋白疗法具有保护性,减少排斥并改善移植的存活率.

科学领域:

移植免疫学移植免疫学
儿科肺病学儿科肺病学
临床研究是临床研究.

背景情况:

急性排斥是肺移植后的常见并发症.
有限的研究存在于儿童肺移植接受者急性排斥的危险因素.
了解这些因素对于改善这一弱势群体的结果至关重要.

研究的目的:

确定与儿科肺移植急性排斥相关的重大风险和保护因素.
调查急性排斥对这个群体的移植失败的影响.
增强儿科肺移植接受者的临床管理策略.

主要方法:

来自器官采购和移植网络 (OPTN) 数据库 (1987-2023) 的906例儿科肺移植病例的回顾性分析.
多变量后勤回归以确定急性排斥的风险和保护因素,调整免疫抑制疗法.
多变量Cox比例危险回归以评估急性排斥和移植失败之间的关联.

主要成果:

循环氨酸维持疗法 (aOR,4.26),缺血时间≥9小时 (aOR,4.73) 和两个HLA-A位点不匹配 (aOR,1.42) 被确定为急性排斥的重要危险因素.
西班牙裔接受者种族 (aOR,0.56) 和抗红细胞球蛋白诱导疗法 (aOR,0.55) 显示出对急性排斥的显著保护作用.
发现急性排斥是移植失败的独立预测因素.

结论:

这项研究概述了儿童肺移植接受者急性排斥的关键风险和保护因素.
调查结果提供了对受体和捐赠者的特征有价值的见解,这些特征影响了排斥风险.
鉴定出来的因素可以为有针对性的干预提供信息,以减轻排斥并改善儿科肺移植中长期移植存活率.

关键词:

肺部移植肺部移植儿科儿科儿科儿科有关风险因素的风险因素.

更多相关视频

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

相关概念视频

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...