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Updated: Apr 30, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
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Published on: July 23, 2016

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时间变异清除的人口药动力学建模实践:从首次在人体上进行的病例研究的见解

Yongjun Hu1, Lan Gao1, Ronald Kong1

  • 1Pharmametrics in Clinical Pharmacology, PTC Therapeutics Inc., 500 Warren Corporate Center Drive, Warren, New Jersey, USA.

Journal of clinical pharmacology
|March 3, 2026
PubMed
概括

这项研究开发了一种药理动力学模型,以准确地描述早期药物开发中的时间变化的清除. 该模型通过解决非线性药理动力学和食效应来改进剂量策略.

关键词:
第一次在人身上 (FIH) 研究.人口药理动力学 (PopPK) 建模时间变化的清除距离.

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