在运动变化下的基于VMAT的全乳房放射治疗中,内部边缘,自动闪光和虚拟玻尿酸的剂量效应
Ji Hyeon Joo1,2, Dong Woon Kim2, Wontaek Kim1,3
1Department of Radiation Oncology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Journal of applied clinical medical physics
|March 3, 2026
概括
自动闪光 (AF) 和虚拟螺旋体 (VB) VMAT技术在全乳房放射治疗中提供了与内部边缘 (INT) 相比更好的稳定性. AF在乳房胀时表现出色,而VB在不完整的喘息期间表现出色,确保更好的目标覆盖.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 癌症治疗 癌症治疗
背景情况:
- 卷度调节弧线疗法 (VMAT) 是一种用于治疗乳腺癌的放射治疗技术.
- 治疗期间的几何变化,如乳房胀和呼吸运动,可能会影响治疗的准确性.
- 评估不同的VMAT规划技术对于优化患者治疗结果至关重要.
研究的目的:
- 评估三种VMAT规划技术的剂量测量性能和稳定性:内部边缘 (INT),自动闪光 (AF) 和虚拟玻尿酸 (VB).
- 模拟整个乳房放射治疗期间的几何变化,包括乳房胀和呼吸运动.
- 为了比较这些技术在不同条件下保持目标覆盖率的有效性.
主要方法:
- 包括9名接受VMAT的左侧乳腺癌患者.
- 我们比较了三个规划技术 (INT,AF,VB).
- 通过移动平面中心 (±3毫米和±5毫米) 模拟呼吸运动,并重新计算剂量分布.
主要成果:
- 所有的技术在静态条件下都提供了足够的目标覆盖.
- 自动闪 (AF) 在模拟乳腺胀期间保持目标覆盖的卓越稳定性 (PTV V95% = 99.10%).
- 虚拟玻尿酸 (VB) 在模拟的不完全启发过程中在保持目标覆盖率方面表现出更大的稳定性 (PTV V95% = 90.46%).
结论:
- 传统的内部边缘 (INT) 技术在VMAT乳腺放射治疗中的几何变化方面不那么强大.
- 自动闪光 (AF) 有效地补偿乳房胀,而虚拟玻尿酸 (VB) 在低于最佳的喘息期间更有效.
- 建议使用表面导向放射治疗和视觉指导来提高治疗的准确性.
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