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Updated: May 6, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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综合性分析确定了一个cGAS-STING路径驱动的签名,在系统性红斑狼中具有上下文依赖的角色

Lele Zhang1, Ming-Ju Amy Lyu1,2, Ze Hong3

  • 1Central Laboratory, Innovation and Incubation Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 3, 2026
PubMed
概括

干扰素基因 (cGAS-STING) 的循环GMP-AMP合成酶刺激通路在全身性红斑狼 (SLE) 中至关重要. 一个新的M7core基因签名量化了途径活性,有助于诊断和预测SLE患者的STING抗剂治疗反应.

关键词:
- / - 小鼠.在Trex1−/−小鼠中.Zbp1−/− 的小鼠.原始诱导的类似狼的小鼠.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.这就是cGAS-STING路径.

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