耐受肠道微生物群的不同含义
Vinicius Mendes Vidal1,2, Elena Montes-Cobos3, Fábio B Canto4,5
1Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
mBio
|March 3, 2026
概括
免疫系统平衡了病原体耐药性与微生物耐受性,这对于宿主微生物组共生至关重要. 现代生活方式破坏了这些耐受机制,可能会增加免疫媒介疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 宿主-微生物相互作用
背景情况:
- 多细胞生命在不断的微生物压力下演变.
- 免疫系统传统上专注于病原体的抵抗力.
- 与宿主特定微生物群的共存也至关重要.
研究的目的:
- 探索宿主微生物关系中的免疫耐受性概念.
- 检查免疫系统如何在微生物刺激中维持功能.
- 研究肠道微生物群在免疫耐受性中的作用.
主要方法:
- 对免疫学耐受性机制的审查.
- 对表皮屏障功能,毒素中和和应激反应在疾病耐受性方面的分析.
- 检查先天免疫 (LPS耐受性) 的表观遗传和代谢重编程.
- 研究肠道微环境在产生宽容细胞和调节性T细胞中的作用.
主要成果:
- 疾病耐受性涉及上皮质完整性,毒素中和,修复和应激反应.
- 暴露于微生物会诱导先天免疫的表观遗传和代谢变化.
- 肠道微环境促进了耐受性抗原呈现细胞和调节性T细胞.
- 洲际蛋白-10 (IL-10) 是连接宽容性通路的关键调解物.
- 微生物群积极诱导宿主耐受性路径.
结论:
- 免疫耐受性对于宿主-微生物群共生至关重要.
- "卫生假设"表明,现代生活方式的变化会破坏耐受性.
- 耐受性受损可能会导致免疫媒介疾病的增加.
- 耐受性机制对于在人类世 (Anthropocene) 中保持健康至关重要.
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