通过初始抗真菌疗法治疗腹腔内候群的临床结果
M Albanell-Fernández1,2, A Vergara3,4,5, F Marco3,4
1Pharmacy Service, Division of Medicines, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain.
Mycoses
|March 3, 2026
概括
腹内角膜炎 (IAC) 是一种严重的感染. 最初的抗真菌选择 (azoles vs echinocandins) 没有影响30天死亡率,但败血症休克和年龄较大增加了风险.
科学领域:
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 腹腔内候群 (IAC) 呈现出显著的发病率和死亡率.
- 了解影响IAC结果的因素对于患者管理至关重要.
研究的目的:
- 根据最初的抗真菌疗法 (azoles与echinocandins) 评估IAC结果.
- 在IAC患者中确定持续感染和30天死亡率的预测因素.
主要方法:
- 对154名成年IAC患者 (2020-2025) 的回顾性单中心研究.
- 亚醇组和雄丹丁组之间的结果比较.
- 使用多变量逻辑回归和IPTW来分析死亡率预测因素.
主要成果:
- 最初的抗真菌治疗没有显著影响30天死亡率.
- 感染性休克和60岁以上的年龄是30天死亡率的重要预测因素.
- 持久的阳性培养与严重的表现有关,如周周炎和候选血症.
结论:
- IAC是一种复杂的感染,死亡率高.
- 虽然 echinocandins 用于重症患者,初始治疗选择没有改变死亡率.
- 严重的呈现因素,而不是最初的抗真菌药物,预测结果更差,死亡率更高.
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