儿童时期的奖励网络连接性预测了青少年时期的多域失调
Eugenia Giampetruzzi1, Parmis Khosravi2, Katharina Kircanski3
1Department of Psychology, Stanford University, Stanford, CA, USA.
概括
青少年多领域失调遵循一个U形轨迹. 较弱的童年奖励网络连接预测了以后失调的增加,这表明了早期干预的目标.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 青春期多域失调是一个重要的跨诊断风险因素.
- 它的发育轨迹和神经支仍然不清楚.
- 改变的奖励网络连接可能是一个早期的神经标记.
研究的目的:
- 调查青春期跨越多域失调的发展过程.
- 检查神经前,特别是奖励网络连接,失调轨迹.
- 识别潜在的风险预测早期标志物.
主要方法:
- 纵向研究包括9-18岁的4项评估.
- 使用青年自我报告失调概况 (YSR-DP) 评估了多领域失调.
- 使用静止状态fMRI测量基线奖励网络连接 (N=94) 和用于轨迹分析的混合效应模型 (N=211).
主要成果:
- 多域失调得分显示出非线性轨迹:下降,然后增加,在青春晚期稳定.
- 较低的基线奖励网络连接预测了从青春期早期到中期更大的失调增加.
- 控制网络的连接性没有预测失调的变化.
结论:
- 多域失调通过青春期表现出明显的非线性发育路径.
- 童年奖励网络连接是升级失调的潜在预测因素.
- 针对儿童后期/青春期早期的奖励处理的干预措施可能是有益的.
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