开发,优化和体外评估滥用威的配方
Jaydip Bhola1, Chetan Borkhataria2
1Gujarat Technological University, Ahmedabad, Gujarat, India. ORCID: https://orcid.org/0000-0002-4318-268X.
Journal of opioid management
|March 3, 2026
概括
这项研究开发了一种新的滥用威剂配方 (ADF),使用化麻油和聚乙烯氧化物. 新配方有效防止药物提取和操纵,为药物提供更安全的替代品.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 是一种材料科学.
背景情况:
- 滥用和滥用药物给公共卫生带来了重大挑战.
- 滥用威配方 (ADF) 对于缓解这些问题至关重要.
- 现有的ADF需要开发可扩展和具有成本效益的制造技术.
研究的目的:
- 开发一种简单,可扩展和具有成本效益的滥用威配方 (ADF).
- 研究化麻油 (HCO) 作为疏水涂料剂的使用.
- 评估聚乙烯氧化物 (PEO) 对配方特性和滥用威的影响.
主要方法:
- 一种新型的ADF是通过涂覆水友性药物分子与疏水性化麻油 (HCO) 来开发的.
- 加入聚乙烯氧化物 (PEO) 来增强机械强度和阻止物理操纵.
- 为了优化HCO和PEO度,采用了32个全因数设计.
- 优化的配方在各种现实条件下进行了测试,并进行了稳定性研究.
主要成果:
- 氧化的疏水涂层成功地减缓了从粉碎配方中提取药物的过程.
- 聚乙烯氧化物 (PEO) 提供了机械完整性,并阻止了物理操作.
- 该配方在与溶剂接触时表现出类似凝的结构,阻止了静脉内滥用.
- 稳定性研究证实了该配方在加速和长期条件下的稳定性为期六个月.
结论:
- 使用HCO和PEO开发的滥用威配方是有效和可扩展的.
- 这种配方为减少药物滥用和滥用提供了一个有希望的战略.
- 这种具有成本效益的技术为制药制造商提供了可行的解决方案.
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