相关实验视频
Updated: Mar 4, 2026

06:49
Automated Gait Analysis in Mice with Chronic Constriction Injury
Published on: October 17, 2017
10.9K
步态作为化疗诱导的外周神经病变严重程度的定量指标:试点研究
Serena Jiyeon Kim1, Patrick Dougherty2, Salahadin Abdi2
1Department of Pain Medicine, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. sjkim4@mdanderson.org.
概括
步行参数客观地衡量化疗诱导的周围神经病变 (CIPN) 的严重程度. 这项试点研究在活跃的CIPN患者中发现了显著的步行障碍,这表明步行分析是评估这种常见化疗副作用的潜在临床工具.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 生物机械工程 生物机械工程
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见,令人衰弱的副作用.
- 患者报告的结果 (PRO) 是评估CIPN的标准,但容易产生偏见和变化.
研究的目的:
- 调查步态参数作为CIPN严重程度的客观指标.
- 为了比较活跃CIPN,已消失的CIPN和健康对照患者的步态.
主要方法:
- 一个27名参与者 (9名活跃CIPN,9名CIPN已解决,9名对照) 的未来病例系列.
- 步行参数 (速度,节奏等) 使用GAITRite®进行测量.
- 分析了步态测量,TNAS疼痛评分和PROMIS® 29+2个人资料评分之间的相关性.
主要成果:
- 活跃的CIPN患者表现出明显的步行障碍 (速度减慢,行走时间延长等). 与已解决的CIPN和对照组相比.
- 在活跃的CIPN患者和对照人群中观察到更高的节奏.
- 步行参数与疼痛评分和功能限制有显著的相关性.
结论:
- 步行参数显示了评估CIPN严重性的客观,有效工具的潜力.
- 需要对更大样本进行进一步的研究,以验证步态分析作为癌症幸存者的临床工具.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
537
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
537
Peripheral Artery Disease IV: Nursing Management
499
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
499
Peripheral Artery Disease I: Introduction
497
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
497

