对于移植不合格的R/R LBCL患者来说,一个新时代:发生了什么变化?
Giuseppe Tarantini1, Rosanna Maria Miccolis1, Elena Arcuti1
1Hematology and Bone Marrow Transplant Unit, Hospital Monsignor R. Dimiccoli, Barletta, Italy.
Leukemia & lymphoma
|March 3, 2026
概括
化学抗原受体 (CAR) T细胞疗法为复发或耐药的大B细胞淋巴瘤 (LBCL) 患者提供了新的希望. 本综述探讨了CAR T细胞和其他新型治疗方法,用于移植不合格的R/R LBCL患者.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 大多数大型B细胞淋巴瘤 (LBCL) 患者在初始治疗后得到缓解.
- 然而,30%-40%的人患有复发性或耐火性疾病 (R/R),历史上使用化疗和自身干细胞移植 (ASCT) 进行治疗.
- 对于初级耐火性或早期复发的LBCL,ASCT提供了有限的益处.
研究的目的:
- 对不符合 ASCT 资格的 R/R LBCL 患者进行治疗选择的审查.
- 为了突出CAR T细胞治疗在这个人群中的有效性.
- 讨论R/R LBCL的新兴治疗方法.
主要方法:
- 对临床试验和研究的审查,重点关注R/R LBCL治疗.
- 分析了TRANSFORM,ZUMA-7和PILOT试验中的数据.
- 检查抗体与药物合物,双特异性抗体和新型免疫疗法.
主要成果:
- 化学抗原受体 (CAR) T细胞疗法,利索卡巴基因maraleucel (liso-cel) 和轴卡巴基因 ciloleucel (axi-cel),已被批准为ASCT合格患者的二线选择.
- 在PILOT研究中,lysocel在ASCT不合格的患者中显示出有效性.
- 其他新疗法在这个具有挑战性的群体中显示出有希望的响应率.
结论:
- 用CAR T细胞治疗显著改善了R/R LBCL的结果.
- 不符合ASCT资格的R/R LBCL患者代表了一个独特的群体,具有特定的治疗需求.
- 一系列新的免疫疗法和向药物为ASCT不合格的R / R LBCL提供了有效的治疗选择.
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