解码Arabidopsis通过ADR1-关联的转录网络进行生长防御权衡
Donghui Hu1, Jinge Wang1, Rachelle R Q Lee1
1Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore.
Cell reports
|March 3, 2026
概括
植物的免疫反应涉及生长和防御之间的权衡. 这项研究表明,免疫信号积极抑制ADR1s介导的生长基因,以平衡这些必要的过程.
科学领域:
- 植物生物学 植物生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 植物生长和防御对于植物健康至关重要,但与它们相反相关.
- 均衡这些过程的监管机制尚未完全理解.
- 增长迟缓的自身免疫植物提供了一个研究这种权衡的模型.
研究的目的:
- 研究植物生长与防御之间的监管权衡.
- 确定关键的遗传模块和参与平衡生长和防御的监管途径.
- 阐明ADR1s在调解生长与防御平衡中的作用.
主要方法:
- 对自身免疫 (DANGEROUS MIX) 和受病原体治疗的Arabidopsis thaliana的转录组分析.
- 分析与生长和防御相关的基因表达模块.
- 在自身免疫植物中编色素可访问性概况.
- 对ADR1基因进行基因操纵.
主要成果:
- 确定了两个主要的转录模块用于防御和生长 (4,712个基因,转录组的17%),显示出一致的对抗性.
- 证明ADR1s (辅助核酸结合的氨酸丰富的重复) 是关键的调节者,逆转表达模式并影响与生长相关的受体类激酶 (RLK) 基因.
- 观察到相互的染色质可访问性变化,增长部位的可访问性降低和自身免疫植物的防御部位的可访问性增加.
结论:
- 免疫信号,部分通过ADR1s,积极抑制生长基因,以管理生长防御权衡.
- ADR1s在调节生长和防御途径之间的平衡方面发挥着重要作用.
- 研究结果表明,一种分子机制可以在免疫和生长之间平衡资源分配.
相关概念视频
Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
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Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...


