在加热的腹腔内化疗废液中对亡标记物的分析与腹腔内转移患者的预后有关
Eran Nizri1,2, Yuval Dranizky1, Kelly Lipczyc1
1Department of Surgery B and Laboratory of Surgical Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Journal of surgical oncology
|March 3, 2026
概括
超热腹腔内化疗 (HIPEC) 废水中的亡标志物可以预测腹腔表面恶性瘤的治疗有效性. 这种新型生物标志物与复发风险降低相关,可能引导辅助治疗决策.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物标志物发现发现
背景情况:
- 腹膜表面恶性瘤 (PSM) 通过细胞还原性手术 (CRS) 和高热性腹膜内化疗 (HIPEC) 进行治疗.
- 需要对HIPEC疗效进行实时评估.
- 在HIPEC废水中瘤细胞的亡被探索为治疗反应的潜在指标.
研究的目的:
- 评估HIPEC废水中的亡标志物作为PSM治疗有效性的生物标志物.
- 为了确定细胞亡水平是否与瘤结果相关.
主要方法:
- 预计将招募44名接受CRS-HIPEC治疗的患者.
- 在HIPEC之前和之后,用Annexin-PI染色的CD45-细胞的流细胞计分析.
- 计算亡反应 (Δapop) 作为HIPEC后亡的增加.
- Δapop与腹腔疾病无生存率 (pDFS) 的相关性.
主要成果:
- 在81.8%的患者中实现了完整的细胞减少.
- 观察到的 Δapop 的中位数为 8.5%.
- 具有显著的亡反应 (响应者) 的患者具有显著更长的pDFS (未达到与16个月相比,p=0.04).
- 亡反应是pDFS的一个独立预测因素 (HR=0.22,p=0.03).
结论:
- 在HIPEC废水中的亡标志物作为治疗有效性的组织学不可知生物标志物.
- 这种测定与PSM患者的复发风险相关.
- 这些发现表明,有可能改善患者选择辅助疗法的可能性.
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