慢性鼻炎中的维生素D状态和补充:系统性审查和元分析
Shuyi Huang1, Xia Li1, Haotian Wu1
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, China.
概括
慢性鼻炎 (CRS) 患者的维生素D水平较低. 补充VD可能为CRS提供短期缓解症状,但长期益处尚未确定.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 慢性鼻炎 (CRS) 是鼻粘膜的普遍炎症状况.
- 维生素D (VD) 在免疫调节中起着至关重要的作用,其缺乏已与各种炎症性疾病有关.
- 血管疾病水平和CRS之间的关联,以及血管疾病补充剂的有效性,需要全面调查.
研究的目的:
- 为了确定血清维生素D (VD) 水平和慢性鼻炎 (CRS) 之间的关系.
- 评估VD补充剂作为CRS症状和结果的治疗干预措施的有效性.
主要方法:
- 在PubMed,Embase和Cochrane图书馆系统地搜索相关研究的文献.
- 对15项研究的元分析,以比较CRS患者和对照人群之间的VD水平.
- 分析了四项随机对照试验 (RCT),用SNOT-22 (Sino-Nasal Outcome Test-22) 评分来评估VD补充对CRS结果的影响.
主要成果:
- 聚合分析显示,与健康对照组相比,CRS患者的血清VD水平显著降低 (SMD = -0.98,P <.001).
- 在有鼻息肉的CRS (CRSwNP) 和没有鼻息肉的CRS (CRSsNP) 分组中,一致观察到较低的VD水平.
- 血管疾病补充剂在SNOT-22得分中显示出显著的短期改善 (<3个月;MD = -1.44,P = .001),但这种效应在更长的时间内没有持续 (≥3个月;P = .12).
结论:
- 患有CRS的个体表现出显著降低的血清维生素D水平.
- 维生素D补充剂可能为CRS患者提供暂时的症状益处.
- 需要进一步的研究来确定VD补充剂的长期疗效和最佳使用,以控制CRS.
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