生物学的深度学习面临着可转移性危机.
Thomas A O'Shea-Wheller1, Katie I Murray2,3
1Environment and Sustainability Institute, University of Exeter, Penryn, Cornwall, United Kingdom.
PLoS biology
|March 3, 2026
概括
可通用模型是深度学习的关键,但错误的可转移性要求阻碍了准确的评估. 本研究解决了生物科学中的这一关键问题,提出了可靠模型评估的解决方案.
科学领域:
- 深度学习是一种深度学习.
- 计算式生物科学 是一种计算式生物科学.
- 模型的概括性 模型的概括性
背景情况:
- 概括性是深度学习研究的一个核心目标.
- 对模型可转移性的误导性说法可能会损害科学完整性和可重复性.
- 准确的绩效评估对于推动生物科学发展至关重要.
研究的目的:
- 突出生物科学中深度学习中误导性的可转移性主张的问题.
- 为了强调这些说法对可靠的绩效评估的负面影响.
- 提出可行的解决方案,以改善模型通用性评估.
主要方法:
- 关于生物科学中的深度学习概括性的文献综述.
- 分析展示可转移性问题的案例研究.
- 开发一个框架来评估模型的通用性.
主要成果:
- 确定了特定情况下,可转让性要求是没有根据的.
- 量化了对研究可重复性的潜在负面影响.
- 建议对模型通用性进行可靠评估的标准.
结论:
- 解决误导性的可转移性主张对于生物科学的科学进步至关重要.
- 实施标准化的评估协议将提高深度学习模型的可靠性.
- 未来的研究应该专注于开发更强大的方法来评估模型通用性.
相关概念视频
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Synthetic Biology
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...


