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Updated: Jun 20, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

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在异质聚合景观中研究的单纤维生长动态

Mahaprasad S R Sahu1, Maria Leslie Kannath2, Yann Fichou3

  • 1Tata Institute of Fundamental Research, Hyderabad, Telangana 500046, India.

The journal of physical chemistry. B
|March 3, 2026
PubMed
概括

研究人员发现了新的蛋白纳米聚合物,与粉样纤维不同,可能会播种病变. 这些稳定的纳米聚合物通过静电相互作用和β片稳定形成,可能在神经退行性疾病的进展中发挥关键作用.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...