在脏患者初级mRNA COVID-19 疫苗接种六个月后,班级转向IgG4
Sophie C Frölke1,2, Kenney G Amirkhan1,3, Nelly van der Bom-Baylon3
1Amsterdam UMC Location University of Amsterdam, Renal Transplant Unit, Amsterdam, the Netherlands.
PloS one
|March 3, 2026
概括
脏患者,包括移植受体,在mRNACOVID-19疫苗接种后显示B细胞反应减少. 幸存者表现出对IgG4抗体的转变,在接种疫苗后持续了六个月.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 在健康人群中,mRNA COVID-19 疫苗诱导了对IgG4抗体的类切换.
- IgG4抗体具有有限的效应功能,这引发了对保护的担忧.
- 疫苗接种后,脏病患者的免疫反应和IgG子类动态尚不清楚.
研究的目的:
- 在mRNA-1273疫苗接种后,评估患者的IgG亚类模式和尖端 (S) 特定的B细胞表型.
- 为了比较移植受体 (KTRs),透析患者和慢性病 (CKD) 患者的免疫反应与健康对照.
主要方法:
- 涉及KTR,透析患者,CKD患者和接受两剂mRNA-1273疫苗的对照组的探索性研究.
- 接种疫苗前收集的血液样本,第二剂接种后的28天和6个月.
- 通过多重免疫测定测量S1特异性IgG抗体;通过流细胞计测定B细胞表型.
主要成果:
- 接种疫苗后,一半的KTRs缺乏可检测的S结合B细胞.
- 在响应者中,S结合B细胞,主要是IgG+等离子体,持续长达6个月.
- 在所有患者组和对照组中都观察到对IgG4抗体的显著转变 (增加IgG4:IgG1比率).
结论:
- 在大多数脏患者中,mRNA疫苗接种引起可检测的S结合B细胞和抗体形成,但大约一半的KTR没有反应.
- 对IgG4抗体的相对转移在脏患者和对照群中持续至少6个月.
- 需要对更大的队列和功能性试验进行进一步的研究,以确定IgG4亚类偏差在这个人群中的临床意义.
相关概念视频
01:28Kidney Transplant I: Introduction
702
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
702
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
490
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
490
01:22Acute Kidney Injury I: Introduction
1.2K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.2K
01:16Kidney Transplant III: Nursing Management
573
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
573
01:26Kidney Transplant II: Surgical Procedure
792
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
792
01:15Transcytosis of IgG
4.5K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.5K