感染中度病毒性ASFV后免疫的持续时间
Virginia Friedrichs1, Paul Deutschmann1, Kerstin Wernike1
1Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Greifswald Insel-Riems, Germany.
PLoS pathogens
|March 3, 2026
概括
从非洲猪瘟病毒 (ASFV) 感染中恢复过来的猪至少有六个月的保护性免疫力. 这种免疫力在随后接触有毒的ASFV菌株时显著降低了疾病的严重程度.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 动物卫生 动物健康
背景情况:
- 非洲猪瘟病毒 (ASFV) 对猪群和猪肉行业构成重大全球威胁.
- 了解ASFV感染后免疫的持续时间对于疾病控制和疫苗开发至关重要.
研究的目的:
- 评估从中度病毒性ASFV感染中恢复的猪的长期免疫力和命运.
- 评估防护效应,以防止随后的挑战与高度毒性的ASFV菌株.
主要方法:
- 猪被注射了一种中度毒性ASFV菌株 (爱沙尼亚14),后来被高毒性菌株 (亚美尼亚08) 挑战.
- 通过临床症状,病毒载量,病毒隔离,抗体动力学 (IgM,IgG) 和补体系统激活 (C3a,C5a) 来评估免疫力.
主要成果:
- 与对照动物相比,恢复过来的猪在挑战时显著减少了临床症状和死亡率.
- 观察到持续IgG水平显示的幽默性免疫,并通过莱克通路观察到补充剂激活.
- 在先前接种疫苗的猪的器官中检测到低水平的传染性病毒,在挑战后的28天内.
结论:
- 对ASFV的保护性免疫可以在中度感染后恢复后至少持续六个月.
- 这些发现支持ASFV疫苗的开发,并为疾病控制策略和监测提供信息.
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