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Updated: May 6, 2026

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
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Published on: June 7, 2016

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增强KCC2功能的作用降低了间活动,并防止叶发作

Florian Donneger1, Adrien Zanin1, Jeremy Besson1

  • 1Institut du Fer à Moulin, Inserm, Sorbonne Université, UMR-S 1270, Paris 75005, France.

Proceedings of the National Academy of Sciences of the United States of America
|March 3, 2026
PubMed
概括

两种化合物,即普罗克佩拉 (PCPZ) 和CLP-257,增强了KCC2的功能,以恢复化物平衡. 这些KCC2增强剂在模型中有效降低了发作,显示了对抗药性半径叶 (mTLE) 的治疗潜力.

关键词:
动物模型动物模型化物运输载体 化物运输器在海马体内,海马体神经药理学神经药理学切除大脑组织的大脑组织.

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