瓦尔酸与双极性障碍中德克斯特罗梅索芬结合的神经保护性,认知性和免疫调节作用
Chih-Chun Huang1, Nian-Sheng Tzeng2, Yun-Hsuan Chang3
1Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Douliu Branch, Yunlin, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Journal of psychiatric research
|March 3, 2026
概括
与酸 (VPA) 配合的辅助德克斯特罗梅索芬 (DM) 在双相情感障碍 (BD) 患者中没有显著的认知或免疫调节益处. 需要进一步的研究来确认DM在BD治疗中的潜在影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 酸 (VPA) 是双相情感障碍 (BD) 的标准治疗方法,具有神经营养特性.
- 德克斯特罗梅索芬 (DM) 具有抗炎和神经保护作用,表明其潜在的治疗价值.
研究的目的:
- 调查是否添加德克斯特罗梅索芬 (DM) 添加到酸 (VPA) 在双相情感障碍 (BD) 中提供额外的认知或免疫调节益处.
主要方法:
- 开放的VPA治疗,然后随机分配到VPA加安慰剂或VPA加延长释放DM12周.
- 评估了神经心理测试 (CPT,WMS-R),症状严重程度,细胞因子水平和BDNF.
- 使用MANOVA来分析随时间推移的群体差异.
主要成果:
- 两组都显示出记忆力,注意力和减少炎症标志物 (TNF-α,CRP,IL-8) 的改善,BDNF的增加.
- 没有发现任何显著的分组时间相互作用,表明VPA加安慰剂和VPA加DM组之间没有差异性治疗效应.
- 探索性分析显示,DM组的数值改善略大,但这些并没有统计学意义.
结论:
- 在BD患者中,辅助DM与VPA单独相比,没有提供统计学上显著的额外认知或免疫调节益处.
- 需要进行长期,盲目,安慰剂对照试验,以最终评估DM作为BD辅助疗法的疗效.
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