在患有慢性疼痛/慢性疲劳的患者中可能发生神经分歧和连接组织变异:一个病例对照研究
Lisa Quadt1, Georgia Savage2, Rod Bond3
1Department of Clinical Neuroscience, Brighton and Sussex Medical School, University of Sussex, BN1 9RY, Brighton, UK; Sussex Neuroscience, School of Life Sciences, University of Sussex, BN1 9RH, Brighton, UK; Sussex Partnership NHS Foundation Trust, Portland House, Richmond Road, BN11 1HS, Worthing, UK.
Journal of psychiatric research
|March 3, 2026
概括
患有慢性疼痛和/或慢性疲劳 (CP/CF) 的人可能患有自闭症和注意力缺陷多动症障碍 (ADHD) 的比例更高. 关节高流动性显著调解了这种联系,这表明需要在CP/CF患者中进行神经分歧查.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 类风湿病学 类风湿病学
背景情况:
- 在患有慢性疼痛和/或慢性疲劳 (CP/CF) 的个体中,神经分离特征很常见.
- 关联神经分歧和CP/CF的机制尚不清楚.
- 关节高移动性是结合组织变异的标志物,在神经分离的群体中越来越多地被识别出来.
研究的目的:
- 确定患有CP/CF的患者可能患有自闭症和注意力缺陷多动性障碍 (ADHD) 的患病率.
- 调查是否关节超流动性介导神经分离特征和CP/CF之间的关系.
- 突出CP/CF中神经分歧的临床意义,以改善患者的支持.
主要方法:
- 一项使用在线调查的病例控制研究.
- 包括83名患有CP/CF的成年人和91名非临床对照.
- 用于自闭症,多动症和关节多动性的验证查工具的管理.
主要成果:
- 与对照组相比,CP/CF患者可能患有自闭症 (aOR 14.3) 和可能患有多动症 (ADHD) (aOR 12.9) 的几率显著更高.
- 发现关节高移动性显著调解神经分离特征与CP/CF之间的关联.
- 统计分析包括二进制物流回归和调解分析.
结论:
- 很大一部分患有CP/CF的个体表现出与自闭症和ADHD相关的特征.
- 关节高移动性在神经分歧和CP/CF之间的联系中起着调解作用.
- 建议在CP/CF患者中进行神经分歧的常规查,以加强获得量身定制的支持并改善生活质量.
更多相关视频
相关概念视频
Connective Tissue Cell Types
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Introduction to Connective Tissues
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...


