有机废物处理:对暴露于真菌毒素的工人的生物监测
Andy Schmied1, Marion Berger1, Lennart Marske1
1Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.
概括
有机废物设施的工人显示职业暴露于脱氧尼瓦伦醇 (DON),一种真菌毒素. 虽然转班后的DON水平较高,但仍低于健康风险值,表明工作环境安全.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 毒理学 毒理学 毒理学
背景情况:
- 含有真菌毒素的生物气溶在有机废物处理设施中释放.
- 职业接触这些生物气溶对工人来说是一个潜在的担忧.
研究的目的:
- 调查有机废物处理设施工人的职业接触菌毒素,特别是脱氧尼瓦伦醇 (DON) 和 ochratoxin A (OTA) 的情况.
- 将工人的真菌毒素水平与对照组进行比较,并评估潜在的健康风险.
主要方法:
- 人类生物监测研究涉及50名工人和37名对照.
- 对10种菌毒素生物标记物的点尿样本的分析,使用液态染色学与双重质谱学.
- 测量脱氧尼瓦伦醇 (DON) 和奥拉托克辛A (OTA) 度的量化.
主要成果:
- 在96%的样本中检测到脱氧尼瓦伦醇 (DON). 与对照人群相比,工人班次后样本中的DON总度显著更高.
- 在工作轮班期间,DON水平增加,但没有超过可容忍的每日摄入量.
- 尿中的OTA水平在工人和对照人群之间没有显著差异,这表明通过饮食暴露.
结论:
- 职业接触DON发生在有机废物处理设施中,但不太可能造成健康风险.
- 在这种情况下,尿液中的OTA水平主要反映了饮食摄入量,而不是职业暴露.
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