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载有奎尔素的微囊调节了辅助剂诱导的关节炎中的肠道血清素,细胞增殖和粘膜结构
Lídia Rodrigues Cicero1, Gleison Daion Piovezana Bossolani1, João Victor Kuller1
1Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, PR, Brazil.
奎尔塞丁微囊降低了炎症,并保护了关节炎的老鼠的内. 这种抗氧化和抗炎化合物在预防关节炎进展和相关肠道损伤方面表现有前途.
科学领域:
- 胃肠道学和免疫学
- 药理学和治疗学 药理学和治疗学
- 营养药和天然产品 营养药和天然产品
背景情况:
- 在老鼠中,辅助剂诱导的关节炎 (AIA) 引发了显著的肠道炎症和直肠的结构损伤.
- 在AIA中,慢性炎症与增加的免疫细胞透,杯状细胞枯竭和膜结构改变有关.
- 奎尔素作为抗氧化剂和抗炎剂在治疗关节炎相关的胃肠道并发症中的作用需要进行调查.
研究的目的:
- 为了评估囊中含有夸塞丁的微囊在患有AIA的老鼠中的抗炎作用.
- 为了确定奎尔丁治疗是否可以防止AIA大鼠肠壁损伤.
- 在AIA的背景下,评估奎尔素对免疫细胞群,粘膜形态测量和细胞增殖的影响.
主要方法:
- 三十只霍尔茨曼大鼠被分为五组:对照组,对照组使用奎思微囊,AIA,AIA使用布洛芬,AIA使用奎思微囊.
- 在60天后收集了杰组织,用于组织学和免疫组织化学分析.
- 评估的参数包括免疫细胞标记物 (CD20+,CD45+,CD68+,CD206+),5-HT+,巨细胞,内皮淋巴细胞,杯状细胞,肠壁形态学和细胞增殖.
主要成果:
- AIA诱导显著的肠道炎症,其特征是免疫细胞透和肠壁 (,密室,粘膜) 缩的增加.
- 装有素的微囊 (AQ组) 显示出抗炎作用,防止杯状细胞枯竭,小扩大,密室深度增加和过度细胞增殖.
- 布洛芬 (AI组) 也表现出抗炎作用,并保护了肠壁,杯细胞和5-HT+细胞.
结论:
- 载有奎尔素的微囊有效地减轻了炎症,并防止了患有AIA的老鼠阴的结构损伤.
- 奎尔作为一种有前途的抗氧化和抗炎化合物,有益于治疗和预防关节炎进展和相关的肠道变化.
- 这些发现支持瑞微囊在治疗影响胃肠道的炎症状况方面的治疗潜力.
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