优化基于生物可访问性的多环芳的饮食暴露和健康风险评估:中国北京的一个案例研究
Yixi Tan1, Zhangwei Wu1, Siqi Xing1
1School of Environment, Beijing Normal University, Beijing 100875, PR China.
Ecotoxicology and environmental safety
|March 3, 2026
概括
在不考虑生物可访问性的情况下,对多环芳 (PAHs) 的饮食暴露被低估了. 这项研究揭示了肉类作为一个关键来源,显著降低估计的癌症风险,当生物可访问性包括在评估.
科学领域:
- 环境化学环境化学
- 食品安全 食品安全
- 毒理学 毒理学 毒理学
背景情况:
- 饮食摄入是人类暴露于多环芳 (PAHs) 的主要途径.
- 传统的暴露评估经常忽视生物可访问性和饮食模式,可能导致偏见的风险估计和来源归因.
- 毒性H-PAHs增加的污染导致主食中子[a]烯等效 (BaPeq) 水平升高.
研究的目的:
- 使用体外消化模型量化各种食品中的PAH污染和生物可访问性.
- 评估生物可访问性对饮食暴露评估和来源归因的影响.
- 通过整合生物可访问性数据来完善风险评估,以改善食品安全管理.
主要方法:
- 在体外胃肠道消化模型的应用,以评估43种常见食品中的15种PAH.
- 分析不同食品类别的PAH污染水平和生物可访问性百分比.
- 开发一个综合暴露模型,包括生物可访问性数据.
主要成果:
- PAH的生物可访问性差异很大 (7.8789.6%),肉类显示高水平 (73.5±23.4%),受脂质的影响,受纤维抑制.
- 纳入生物可访问性将主要的食PAH来源从谷物转移到肉类.
- 生物可访问的PAH暴露是总外部暴露的43.9%,将估计的人口癌症风险从99.8%降低到45.4%.
结论:
- 生物可访问性对于准确的内部暴露评估和识别PAHs的真实饮食暴露来源至关重要.
- 忽视生物可访问性可能会扭曲来源归因并高估健康风险.
- 开发的数据集和模型为优化暴露评估和食品安全战略提供了科学基础.
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