在失言症中增强振荡性功能障碍:连接性跨骨交流电刺激的相位依赖网络效应
Chester Yee-Nok Cheung1, Anthony Pak-Hin Kong1
1The Aphasia Research and Therapy (ART) Laboratory, Academic Unit of Human Communication, Learning, and Development (HCLD), Faculty of Education, The University of Hong Kong, Hong Kong, Hong Kong.
概括
连接性横交替电流刺激 (tACS) 在中风后失语症 (PSA) 治疗方面表现有前途. 阶段式tACS在一般网络中增强了连接性,而反阶段式tACS对个性化中断网络有效.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 连接体跨交替电流刺激 (tACS) 使用网络模型指导大脑刺激.
- 之前的研究表明,tACS可用于调节中风后失语症 (PSA) 功能障碍症中的连接性.
- 在相相对抗相tACS对这些网络的具体影响仍然不清楚.
研究的目的:
- 研究在相位和反相位tACS对功能障碍瘤的影响.
- 检查 dysfunctome 中的集中边缘的向如何影响结果.
- 探索个性化准削弱边缘的调节作用.
主要方法:
- 9名PSA患者接受了10Hz tACS与语音治疗相结合的5种条件:通用化相位 (GI),通用化反相位 (GA),个性化相位 (II),个性化反相位 (IA) 和假冒.
- 一般化条件针对的是普遍的高中心性边缘;个性化条件针对的是独特的弱化边缘.
- 功能障碍和网络变化在各个条件之间进行了比较.
主要成果:
- 与假的相比,一般化在相 (GI) 和个体化反相 (IA) tACS显示了与假的相比,平均功能障碍连接率的中等,边际显著增加.
- 在一般化和个性化条件之间观察到相位依赖的效应逆转.
- 目标边缘的基线连接似乎可以缓解tACS效应.
结论:
- 在相位的tACS可能会增强整个功能障碍,当应用到一个不打断的中央边缘时.
- 反相tACS对于被破坏的单个边缘似乎更有效,可能是通过网络重组.
- 这些发现表明tACS在PSA和其他网络障碍中具有精确神经康复的潜力.
相关概念视频
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