植物性饮食指数与乳腺癌风险之间的关联按更年期和激素受体状态分层:韩国女性的病例对照研究
Jeonghee Lee1, Hyeongyeong Lee1, Madhawa Gunathilake1
1Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.
Journal of Korean medical science
|March 3, 2026
概括
较高的植物性饮食指数 (PDI) 与韩国女性乳腺癌风险降低有关. 不健康的植物性饮食 (uPDI) 显示风险增加,特别是在绝经前和绝经后的妇女中.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 乳腺癌仍然是全球妇女的重大健康问题.
- 饮食模式,包括植物性饮食,越来越多地被认为对预防癌症的作用.
- 了解植物性饮食指数对乳腺癌风险的具体影响对于公共卫生至关重要.
研究的目的:
- 研究植物性饮食指数 (PDI) 与韩国女性乳腺癌风险之间的关联.
- 根据更年期状态来探索这种关联中的潜在差异.
- 根据雌激素受体 (ER) 和孕激素受体 (PR) 状态来检查风险的变化.
主要方法:
- 一项涉及395名乳腺癌患者和395名年龄匹配对照的病例控制研究.
- 评估饮食摄入量使用106项半定量食物频率问卷来计算PDI,健康的PDI (hPDI) 和不健康的PDI (uPDI).
- 后勤回归分析用于估计赔率比率和95%置信区间,调整混因子.
主要成果:
- 总体较高的PDI与乳腺癌风险相反相关.
- 不健康的植物性饮食指数 (uPDI) 与乳腺癌风险有关.
- 分层分析显示,在绝经前妇女中,PDI的反向关联,在绝经前和绝经后妇女中,PDI的积极关联. 在ER+/PR+组中,PDI和UPDI的关联较强.
结论:
- 植物性食品的摄入量增加,如PDI较高所示,与乳腺癌的几率较低有关.
- 预防乳腺癌的饮食建议应鼓励食用植物性食品,限制动物性食品的摄入量.
- 这些发现强调了饮食质量在植物性饮食模式和乳腺癌特定受体亚型中的重要性.
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