患有喘的成年人患者患者报告结果的最小临床重要差异:系统性审查
Luoqi Lin1, Fanggang Zhu1, Jingmin Xiao2
1State Key Laboratory of Traditional Chinese Medicine Syndrome/The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Respiratory medicine
|March 3, 2026
概括
解释喘患者的结果需要知道患者报告的结果措施 (PROM) 的临床重要差异最小值 (MCID). 这次审查发现,许多喘PROM缺乏可靠的MCID值,突出了对标准化估计方法的需求.
科学领域:
- 肺部医学 肺部医学
- 临床试验 临床试验
- 健康 结果 研究 研究 结果
背景情况:
- 在临床试验中,患者报告的结果测量 (PROM) 对于评估喘症状控制和生活质量至关重要.
- 解释PROM得分的变化需要了解临床重要差异最小值 (MCID).
研究的目的:
- 确定具有已确定的MCID值的喘特异性PROM.
- 概述在喘研究中使用的MCID估计方法.
- 评估基于的MCID成年喘估计的可信性.
主要方法:
- 按照PRISMA指南进行系统的文献搜索 (PubMed,Embase,科学网).
- 包括报告成人喘特异性PROM的MCID值的原始研究.
- 研究特征,估计方法和可信度评估的叙述总结.
主要成果:
- 19项研究确定了15种喘特异性PROM,其中21种MCID估计.
- 大多数MCID估计来自持续性喘患者群体;很少有人专注于严重的喘或过敏性鼻炎.
- 基于的方法很常见,但由于方法上的局限性,只有15%的MCID估计具有高可信度.
结论:
- MCID值对于喘研究至关重要,但表现出显著的方法变化.
- 需要标准化和透明的MCID估计来提高喘研究的有效性和临床实用性.
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