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2型糖尿病患者尿路感染的病因描述和临床预测模型的构建:一项回顾性研究
Chaofei Zhao1, Yue Li2, Ao Wu3
1Department of Urology III, Tangshan Workers' Hospital, 063000 Tangshan, Hebei, China.
Archivos espanoles de urologia
|March 3, 2026
概括
尿路感染 (UTI) 在2型糖尿病中很常见. 糖尿病持续时间较长,HbA1c,SGLT2抑制剂和白蛋白水平较高,会增加T2DM患者的尿路感染风险.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 传染性疾病 传染性疾病
背景情况:
- 2型糖尿病 (T2DM) 与尿路感染 (UTI) 的风险增加有关.
- 了解T2DM患者尿路感染的特定风险因素对于有效的预防和管理至关重要.
研究的目的:
- 在T2DM患者中确定尿路感染的病因和危险因素.
- 开发一个预测模型,以此种人群的尿路感染.
主要方法:
- 从269名T2DM患者 (2023年1月至2025年1月) 的临床数据的回顾性分析.
- 患者被分为感染和控制组.
- 使用多变量逻辑回归和ROC曲线分析来识别风险因素并评估预测模型,数据分为培训和验证集.
主要成果:
- 在T2DM患者中尿路感染的发病率为18.59% (269例中50例).
- 在T2DM中,尿路感染的独立风险因素包括糖尿病持续时间较长,糖化血红蛋白 (HbA1c) 高,以及依赖的葡萄糖转运体2 (SGLT2) 抑制剂和白蛋白 (ALB) 的水平较高.
- 开发的预测模型在训练 (0.806) 和验证 (0.877) 组中都表现出良好的性能,ROC曲线下的高面积.
结论:
- 糖尿病持续时间,HbA1c,SGLT2抑制剂和ALB水平是T2DM患者尿路感染的重要危险因素.
- 这些指标需要在临床实践中密切监测,以预防T2DM的尿路感染.
- 已建立的预测模型显示,有望用于识别具有尿路感染高风险的T2DM患者.
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