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在地下水中更高的暴露与中风发病率和死亡率的降低有关
Jiajun Luo1, Zhihao Jin2, Yuqing Yang3
1Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, China.
概括
饮用水中天然存在的含量较高,与降低中风风险和死亡率有关. 然而,低至中等度的对预防中风没有显著的益处.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 地质化学 地质化学
背景情况:
- 饮用水中的已经显示出对中风的潜在益处,但其对人口水平的影响尚不清楚.
- 之前的研究表明,与改善中风的结果之间存在联系.
- 环境暴露与一般人群中风风险之间的关系需要进一步研究.
研究的目的:
- 调查饮用水中的环境暴露与中风风险之间的关联.
- 评估地下水中的更高度是否与中风发病率和死亡率的降低相关.
- 为了确定暴露在潜在的中风风险降低的门.
主要方法:
- 评估了美国地下水中的含量,使用了4700个井的数据.
- 在3,108个县 (2015-2019) 进行了度和中风死亡率的生态分析.
- 通过使用电子健康记录和Cox模型对303,153名来自我们所有人研究计划的成年人进行了个体级别分析.
主要成果:
- 生态分析:每次的四分位数间范围 (IQR) 增加与每10万中风死亡人数减少8.2个相关.
- 在暴露的最高四分位数 (>23.3μg/L) 中,与最低四分位数相比,每10万人死亡人数减少了22.6人.
- 个人分析:每次IQR增加都与23%的中风风险降低有关;最高四分位数 (>17.7μg/L) 显示风险降低了52%.
结论:
- 美国地下水中自然存在的的度较高与中风死亡率和发病率的降低有关.
- 环境暴露的低到中等水平似乎对预防中风没有显著的益处.
- 研究结果表明,暴露和中风风险降低之间存在剂量依赖的关系.
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