法国PCSK9抑制剂的使用模式来自全国重复的横截面和队列研究
Allison Singier1, Anne Bénard-Laribière1, Ana Jarne-Munoz1
1University of Bordeaux, INSERM, BPH, Team AHeaD, U1219, 33000, Bordeaux, France.
Scientific reports
|March 3, 2026
概括
新的分析显示,法国PCSK9抑制剂 (PCSK9i) 的使用在扩大适应症后显著增加,但随着补偿控制而放缓. 大多数新用户都是高风险的,之前使用过不同的降脂剂.
科学领域:
- 心脏病学 心脏病学
- 药物经济学 药物经济学
- 公共卫生 公共卫生
背景情况:
- 蛋白转化酶亚素/素9型 (PCSK9) 抑制剂对于管理高胆固醇血症和降低动脉样硬化心血管疾病 (ASCVD) 风险至关重要.
- 了解PCSK9抑制剂 (PCSK9i) 的实际利用模式对于优化治疗策略至关重要.
研究的目的:
- 调查法国PCSK9i (阿利洛马布和埃沃洛马布) 的使用模式.
- 描述PCSK9i的新用户,并描述他们之前和之后使用降脂剂 (LLA).
主要方法:
- 从2018年到2021年利用法国全国医疗保险系统数据库 (SNDS) 进行的横截面和队列研究.
- 分析包括6891名新的PCSK9i用户,检查人口统计,心血管风险和PCSK9i启动前后的LLA治疗轨迹.
主要成果:
- PCSK9i使用在指示后迅速扩张,但在2020年12月实施先前退款协议后放缓.
- 在新的PCSK9i用户中,65.7%是男性,63.7%有非常高的心血管风险,平均年龄为64岁.
- 在没有先前治疗的患者 (17.3%) 中,与先前接受低/中等 (4.9%) 或高强度 (1.3%) 治疗的患者相比,在PCSK9i开始后停止LLA更为常见.
结论:
- 之前的退款协议在规范PCSK9i使用方面显得有效,确保对高风险的高治疗持续性患者提供适当的处方.
- 现实世界的数据强调了在启动PCSK9抑制剂时先前评估LLA强度的重要性.
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