与基于肌素的eGFR和基于cystatin C的eGFR的升高相关的不同心血管风险
Mengyi Liu1, Ziliang Ye1, Panpan He1
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, 510515, Guangzhou, China.
NPJ cardiovascular health
|March 3, 2026
概括
功能标志物升高显示出不同的心血管风险. 基于肌素的高EGFR (eGFRcr) 增加了心血管疾病 (CVD) 的风险,而基于囊素的高EGFR (eGFRcys) 降低了风险. 两者都能降低慢性病 (CKD) 的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 估计的膜过率 (eGFR) 对于评估功能至关重要.
- 两种常见的标记物,肌素 (eGFRcr) 和囊素C (eGFRcys),用于估计eGFR.
- 提升eGFR与心血管疾病 (CVD) 和慢性病 (CKD) 风险的关联需要进一步澄清.
研究的目的:
- 为了比较高的eGFRcr和eGFRcys与发生心血管疾病和CKD的风险的关联.
- 为了调查与高功能相关的差异性风险,基于肌素与囊素C的估计.
主要方法:
- 来自英国生物库的372,060名参与者的队列研究,最初没有CVD和CKD.
- 参与者根据年龄和性别特定百分比分为低,正常和高的eGFR组.
- 主要结局:发生心血管疾病 (缺血性心脏病,中风,心力衰竭,心房动) 在中位数12.4年的随访期间.
主要成果:
- 高的eGFRcr与显著更高的心血管疾病风险相关 (HR,1.19).
- 高的eGFRcys与显著降低心血管疾病风险相关 (HR,0.90).
- 高高的eGFRcr和高高的eGFRcys都与较低的CKD风险有关.
结论:
- 升高的eGFRcr与心血管疾病风险增加有关,与与心血管疾病风险降低相关的eGFRcys形成对比.
- 这两种功能升高的标志物都与患CKD的风险降低有关.
- 这些发现凸显了eGFR估计方法在CVD和CKD风险评估中的重要性.
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