控制与突出:昼夜大脑与身体组织的新轴
Olivier Demers1, Sanaz Ghaffari2, Chen Li2
1Department of Electrical and Computer Engineering, Université de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
Npj biological timing and sleep
|March 3, 2026
概括
循环健康不仅仅是弱强,而是沿着控制-食轴组织起来. 这个轴将运动动力 (ACC) 和自主 (BPM) 节奏与不同的大脑网络连接模式联系起来.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 系统生物学 系统生物学
背景情况:
- 循环节强度通常被视为一个简单的弱强连续.
- 新兴的多系统数据表明,昼夜节律的组织更加复杂.
研究的目的:
- 通过使用多系统数据,调查潜在的昼夜强度的大脑和身体组织.
- 识别昼夜组织的不同原型及其神经相关物.
主要方法:
- 从52名健康的年轻成年人中收集了30天的可穿戴运动器 (加速计;ACC) 和自主 (心率;BPM) 信号.
- 配对可穿戴数据与结构性和静止状态功能性MRI (fMRI).
- 分析了个人级别的昼夜特征向量 (稳定性,振幅,形,ACC-BPM对齐/滞后).
主要成果:
- 发现了大脑与身体组织的控制与食轴.
- 确定了一个控制定的原型 (ACC主导的节奏,更强的认知控制网络) 和一个突出定的原型 (BPM主导的节奏,更强的突出/注意网络).
- 发现跨系统对齐 (ACC-BPM滞后) 追踪了控制网络的一致性,而节奏时间/振幅与皮层几何和网络强度相关.
结论:
- 循环健康是以轴为基础和系统为特征的,从稳定性定,运动驱动到合定,自主主导的配置文件的频谱中组织.
- 控制 - 盐分轴完善了昼夜风险的机械模型.
- 建议针对昼夜健康监测和干预的对齐意识,网络准的策略.
相关概念视频
Biological Clocks and Seasonal Responses
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Diencephalon: Hypothalamus and Coordination
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Brainstem: Control Centers of Medulla
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...


