微量矿物质度与ADHD儿童氧化应激之间的关联 补充多营养素
Lisa M Robinette1, Irene E Hatsu2,3, Chieh-Ming Wu4
1Department of Human Sciences, The Ohio State University, 29 W. Woodruff Ave, 160 Ramseyer Hall, OH, 43210, Columbus, USA.
Biological trace element research
|March 3, 2026
概括
和等微量元素可以改善儿童的抗氧化反应,但高可能会降低它们. 一些矿物质,如,也可能具有亲氧化作用,需要进一步研究.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 儿科健康 儿科健康
背景情况:
- 氧化应激 (OS) 是由于反应性氧物种 (ROS) 生成和抗氧化防御之间的不平衡造成的.
- 微量元素的含量和成分显著影响OS和抗氧化能力.
- 之前的研究表明,多营养补充剂后,ADHD儿童的行为改善.
研究的目的:
- 为了研究血矿物质和OS相关参数在接受多营养补充剂的儿童之间的关系.
- 分析特定的微量元素如何影响生物抗氧化潜力 (BAP),谷氨过氧化酶 (GPx) 和活性氧代谢物 (ROM).
主要方法:
- 对青少年多动症微量营养素的二次分析 (MADDY) 随机对照试验数据.
- 检查了71名儿童的血矿物质含量和OS标记 (BAP,GPx,GR,ROM) (44名多营养,27名安慰剂).
- 利用相关性和适度分析来评估矿物质和OS参数之间的关系.
主要成果:
- 和与GPx变化正相关,表明抗氧化剂反应得到改善.
- 在多营养组中,与BAP呈反向关系.
- 基线,和适度的BAP变化,低/和高与BAP增加相关,在补充组.
- 表现出潜在的亲氧化作用,与多营养组的ROM增加相关.
- 铜是积极预测和与ROM变化相关的,而则显示出负相关性.
结论:
- 多种营养素补充剂可以增强低和血的儿童的抗氧化防御.
- 和的潜在亲氧化作用需要进一步研究,特别是在基线水平较高的儿童中.
- 微量元素状态对于调节儿童的氧化应激和抗氧化能力至关重要.
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