在有或没有严重抑郁症的年轻成年人中,ATP生物能量和疲劳
Kathryn R Cullen1, Susannah J Tye2,3, Bonnie Klimes-Dougan4
1Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Minnesota, Minneapolis, MN, USA. rega0026@umn.edu.
Translational psychiatry
|March 3, 2026
概括
早期主要抑郁症 (MDD) 疲劳与大脑和血液中腺三酸盐 (ATP) 水平的改变有关. 这项研究揭示了MDD的年轻成年人独特的ATP生物签名,这表明了早期的补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 疲劳是主要抑郁障碍 (MDD) 的重要和具有挑战性的症状.
- 了解MDD疲劳的早期分子基础对于预防长期残疾至关重要.
- 生物能量机制,特别是腺三酸盐 (ATP) 代谢,与疲劳有关.
研究的目的:
- 通过检查大脑和血液细胞中的ATP代谢来研究早期MDD疲劳的分子基础.
- 为了比较年轻成年人的ATP度和产量,MDD与健康对照 (HC) 相比.
主要方法:
- 使用P磁共振光谱成像与磁化转移 (P MRSI-MT) 在7特斯拉测量视觉皮层中的ATP.
- 在静止状态下和线粒体抑制后,在周围血液单核细胞 (PBMC) 中测量ATP水平.
- 与疲劳严重程度量表 (FSS) 成绩相关的ATP发现.
主要成果:
- MDD组显示视觉皮层ATP生产率较高,与FSS分数呈正相关.
- 在MDD组的PBMC中观察到较高的ATP度,也与FSS得分相关.
- 与HC相比,MDD PBMC在线粒体脱后表现出较低的ATP生产能力.
结论:
- 这项研究首次证实了MDD的年轻成年人疲劳的ATP生物签名,可在大脑和外周血液中检测到.
- 这些发现表明,在MDD的疾病进展中,早期的补偿生物能量机制存在.
- 改变ATP代谢可能是导致早期抑郁症疲劳的关键分子因素.
相关概念视频
01:37Mitochondria
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
01:24Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
01:21Fatigue
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
01:23ATP and Energy Production
Adenosine triphosphate (ATP) is a critical molecule that functions as the main energy carrier in cells. Structurally, ATP consists of an adenosine molecule—comprising adenine and ribose—bonded to three phosphate groups. The high-energy bonds between these phosphate groups store significant amounts of potential energy. This energy is released during hydrolysis, wherein ATP is converted to adenosine diphosphate (ADP) or adenosine monophosphate (AMP), driving a variety of essential cellular...