老龄化和癌症风险增加:探索LE8得分的潜力,以减轻风险风险
Jiehui Li1, Yuhan Zhang1, Wenxing Zhang1
1Department of Gastrointestinal Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
生物衰老会增加癌症的风险,但采用健康的生活方式因素,如生活必需品8 (LE8) 可以减轻这种风险. 较高的LE8得分与减少癌症发病率有关,特别是在老年人群中.
科学领域:
- 老年病学和瘤学
- 人口健康和流行病学
背景情况:
- 全球人口老龄化需要了解与老龄化相关的癌症风险.
- 缺乏逆转衰老疗法凸显了对癌症预防策略的需求.
- 生物衰老标志物提供了对健康和疾病风险的洞察力.
研究的目的:
- 研究生物衰老标志物与整体/特定部位癌症风险之间的关联.
- 评估生活必需品8 (LE8) 评分对老年人癌症风险的影响.
- 探索潜在的癌症预防策略通过生活方式的修改在老龄化人口.
主要方法:
- 基于人口的队列研究,使用英国生物库数据.
- 使用Klemera-Doubal方法 (KDM),PhenoAge,白细胞端粒长度 (TL) 和时间学年龄来评估衰老.
- 用错误发现率 (FDR) 校正方法分析癌症风险关联和与生活必需品8 (LE8) 的相互作用.
主要成果:
- 所有的衰老指标都显著与整体癌症风险的增加有关.
- 生物衰老与七种特定部位癌症 (食道癌,结肠直肠癌,胰腺癌,皮肤癌,脏癌,尿道癌,淋巴瘤癌) 的风险增加有关.
- 较高的LE8得分表明,在生物学上较年长的个体中,整体癌症和特定癌症 (食道,胃,乳腺,子宫) 的风险降低.
结论:
- 生物衰老是各种癌症的重要危险因素.
- 遵守生命的基本8 (LE8) 准则与降低癌症风险有关,特别是在老年人中.
- 在人口老龄化背景下,LE8代表了癌症预防的可修改因素.
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