在接受冠状动脉和外周血管造影的个人中,BAG3度和心力衰竭事件
Margot De Marco1,2,3, Anna Basile1,4, Alessandra Rosati1,2,3
1Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy.
NPJ cardiovascular health
|March 3, 2026
概括
血液中BAG3水平升高可以预测心血管死亡和主要心血管不良事件. 这种生物标志物表明,即使在症状出现之前,心力衰竭患者的早期风险分层可能存在.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 心脏衰竭研究研究
背景情况:
- 心力衰竭 (HF) 构成了全球严重的健康负担.
- 早期识别和风险分层对于有效的高频管理至关重要.
- 特定生物标志物的作用在预测HF进展方面需要进一步研究.
研究的目的:
- 评估循环BAG3作为心力衰竭普遍定义 (UDHF) 所有阶段的生物标志物的作用.
- 确定BAG3水平是否可以预测不良心血管结果,包括心血管死亡和主要不良心血管事件 (MACE).
- 评估BAG3在心力衰竭无症状阶段的预后价值.
主要方法:
- 来自1121名接受血管造影的个人血样本的分析.
- 采用了一种新的测定方法来测量循环中的BAG3度.
- 统计分析包括危险比率 (HR) 和p值以评估预测值.
主要成果:
- 在整体队列中,较高的BAG3度与心血管死亡 (HR=1.18,p=0.001) 和MACE (HR=1.12,p=0.006) 的风险增加有关.
- 在无症状的HF阶段 (A和B),高的BAG3预测了第一个症状的HF事件 (HR=1.13,p=0.05).
- BAG3还预测了早期后续HF事件的总负担.
结论:
- 循环的BAG3证明了整个心力衰竭谱的预后价值.
- 在无症状阶段BAG3的预测能力表明在HF病变发生过程中具有潜在的功能作用.
- BAG3测量可能对心血管疾病的风险分层和管理策略提供实用性,从早期无症状阶段开始.
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