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与Sintilimab相关的自身免疫性心肌炎和急性心肌梗塞之间的差异诊断

Yihe Wu^1,2, Jiayun Nian¹, Hongxu Liu³

¹Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

Biological procedures online

|March 3, 2026

概括

与sintilimab相关的自身免疫性心肌炎在老年男性中呈现非特异性症状,通常在治疗早期发生. 区分它与急性心肌梗塞需要仔细审查药物史和诊断测试,如心脏MRI.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
心脏病学心脏病学

背景情况:

免疫检查点抑制剂如sintilimab可以诱导与免疫相关的不良事件.
自身免疫性心肌炎是一种罕见但严重的Sintilimab治疗副作用.
从临床上来说,区分辛提利马布诱导的心肌炎与急性心肌梗塞是具有挑战性的.

研究的目的:

分析与sintilimab相关的自身免疫性心肌炎的临床特征和诊断模式.
确定与sintilimab相关的自身免疫性心肌炎和急性心肌梗塞之间的关键差异诊断点.

主要方法:

系统地在文献中搜索与sintilimab相关的自身免疫性心肌炎病例报告,直到2024年4月.
过去三年来北京传统中医医院的医疗记录的回顾性分析.
收集的病例报告和医疗记录经过统计分析.

主要成果:

分析了23个病例 (22个病例报告,1个医疗记录).
受影响的个体主要是老年男性 (60-75岁),通常在第一和第二剂 sintilimab 剂量之间出现.
常见的症状包括胸部紧张和心,偶尔会出现类似于脑筋疲劳症的症状;心脏生物标志物和心电图变化是常见的,而减少的射出分数是罕见的.

结论:

与sintilimab相关的自身免疫性心肌炎表现出非特异性的临床表现.
药物史和相关症状对于早期怀疑至关重要.
冠状动脉扫描,心血管磁共振和心肌活检有助于诊断和区分急性心肌梗塞.

关键词:

剧烈的心肌梗塞急性心肌梗塞自体免疫性心肌炎差异诊断是一种差异诊断.免疫检查点抑制剂免疫检查点抑制剂这就是Sintilimab.

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