相关实验视频

Updated: May 1, 2026

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model

Published on: November 9, 2018

韦扬通格鲁粒通过PPARγ/NF-κB/CDX2信号通路减轻胃肠道代谢

Yimin Liang^1,2, Shijie Su^1,2,3,4, Ting Jin^1,2

¹The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.

Chinese medicine

|March 3, 2026

概括

扬通颗粒 (WYTLG) 在治疗胃肠转化症 (GIM),一种癌前疾病方面表现有前途. 这种传统中医药配方通过调节PPARγ/NF-κB/CDX2通路而起作用,为胃癌预防提供了潜在的策略.

科学领域:

胃肠病学胃肠病学
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

胃肠转化症 (GIM) 是一种癌前疾病,具有显著的胃癌风险,没有有效的治疗方法.
传统中医药 (TCM) 的韦通颗粒 (WYTLG) 显示了GIM的临床潜力,但其机制尚不清楚.

研究的目的:

为了研究WYTLG对GIM的治疗作用.
阐明WYTLG对GIM的作用背后的分子机制.

主要方法:

一种使用体内,体外和体方法的综合方法.
在老鼠和细胞中建立了GIM模型;进行了转录基因分析和分子对接.
机械学的发现通过细胞实验得到了验证.

主要成果:

根据剂量,WYTLG治疗在大鼠模型中改善了胃损伤和GIM,减少了炎症和亡.
转录组分析确定了PPARγ/NF-κB信号通路作为一个关键机制.
分子对接证实了WYTLG化合物和途径标之间有利的结合亲缘关系.

结论:

通过调节PPARγ/NF-κB/CDX2轴,WYTLG可以减轻GIM的进展.
这为防止胃恶性转变提供了潜在的策略.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.胃肠道转化成形症.在PPARγ/NF-κB/CDX2信号通路中.传统的中国医学是传统的中国医学.文字转录学 (Transcriptomics) 是一个学科.威洋通格鲁子颗粒威洋通格鲁子颗粒

更多相关视频

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

相关概念视频

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...