Dot1L的甲基转移酶活性对于Xenopus tropicalis幼的发育和生存至关重要

Emeric M Louis1,2, Nga Luu1, Laurent M Sachs2

  • 1Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Cell & bioscience
|March 3, 2026
PubMed
概括

通过DOT1L对H3 lysine 79 (H3K79) 的甲基化对Xenopus tropicalis发育至关重要. 失去H3K79甲基化导致发育致死性和生长延迟,强调其关键作用.