三甘油-葡萄糖-身体形状指数 (TyG-ABSI) 在评估中风中的价值:一个多中心横截面研究
Hanlin Liu1, Mingxiao Li2, Ziyi Zhang1
1China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
European journal of medical research
|March 3, 2026
概括
甘油三指数-葡萄糖指数-身体形状指数 (TyG-ABSI) 与中风风险增加有关. 这一新型指标可能有助于制定预防中风的公共卫生政策.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征标志物 代谢综合征标志物
- 生物统计学 生物统计学
背景情况:
- 卒中是全球死亡和残疾的主要原因之一.
- 一个身体形状指数 (ABSI) 量化身体形状.
- 甘油三指数-葡萄糖指数-身体形状指数 (TyG-ABSI) 是一种新的复合标记.
研究的目的:
- 为了研究TyG-ABSI和中风之间的关联.
- 评估TyG-ABSI作为潜在的中风风险指标.
主要方法:
- 使用NHANES (美国) 和CHARLS (中国) 数据集进行的多中心横截面研究.
- 多变量逻辑回归,子组分析和受限立方线回归 (RCS).
- 机器学习模型 (例如,梯度增强机) 和SHAP算法评估了辨别能力.
主要成果:
- 在两个队列中,TyG-ABSI和中风之间发现了积极的关联 (OR > 1.18).
- 在没有高血压 (NHANES) 的非老年人中,这种关联更为强烈.
- 观察到一种线性关系,没有值效应;GBM显示出良好的区分能力 (AUC高达0.784).
结论:
- TyG-ABSI与中风风险有积极的关联.
- TyG-ABSI可以作为中风的有价值指标.
- 研究结果可以为预防中风的公共卫生政策提供信息.
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