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A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
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在肠上皮细胞中的ACE2激活可以防止辐射诱导的肠损伤.

Xinglei Song1, Renjun Peng2, Zhongmin Chen2

  • 1The Postgraduate Training Base of Jinzhou Medical University, The Characteristic Medical Center of PLA Rocket Force, Beijing, China.

Antioxidants & redox signaling
|March 4, 2026
PubMed
概括

使用DIZE激活ACE2通路可以保护肠道干细胞免受辐射损伤,改善存活率而不影响瘤的辐射敏感性. 这为放射治疗患者提供了一个新的策略.

关键词:
在ACE2中,ACE2是ACE2.这就是MAPK/NF-κBB.迪米纳酸酸盐是什么意思肠道上皮细胞 肠道上皮细胞辐射引起的肠道损伤

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科学领域:

  • 分子生物学分子生物学
  • 辐射疗法 辐射疗法
  • 胃肠病学 胃肠病学

背景情况:

  • 辐射诱导的肠损伤 (RIII) 是用于腹部/盆腔癌的放射治疗的严重副作用.
  • ACE2/Ang-(1-7) /MasR轴是一个具有潜在抗炎作用的保护性通路.
  • 针对这一轴可能提供一种新的方法来缓解RIII.

研究的目的:

  • 调查ACE2激活在减轻辐射诱导肠道损伤 (RIII) 的作用.
  • 探索肠道中ACE2介导的辐射保护的潜在机制.
  • 评估ACE2激活是否影响瘤的辐射敏感性.

主要方法:

  • 在致命的辐射之前,小鼠接受了选择性ACE2激动剂diminazene aceteturate (DIZE) 的治疗.
  • 评估了对肠道干细胞 (ISC),密室再生,上皮屏障完整性和存活率的影响.
  • 使用人类肠上皮细胞 (HIEC) 和内皮细胞进行了体外研究,并进行了瘤辐射敏感性测定.

主要成果:

  • DIZE治疗保护了ISCs免受辐射引起的死亡,增强了密室再生,保持了屏障完整性,并减少了炎症,显著改善了小鼠的生存率.
  • 辐射保护作用依赖于ACE2和MasR,而DIZE抑制了辐射诱导的MAPK和NF-κB通路,特别是在肠道上皮细胞中.
  • 在体外或体内,DIZE并没有保护内皮细胞,也没有损害结直肠瘤细胞的放射敏感性.

结论:

  • 通过DIZE激活ACE2,通过抑制MAPK/NF-κB信号传递,选择性地保护肠上皮细胞免受辐射损伤.
  • 这种选择性保护可以改善肠道完整性和生存,而不会影响瘤的放射敏感性.
  • 准ACE2通路是一种有前途的治疗策略,可以在接受放射治疗的癌症患者中缓解RIII.