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Updated: May 8, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

探索由药物点中广泛的蛋白质形状变化驱动的神秘口袋形成的结构基础

Martijn P Bemelmans1,2, Alberto Borsatto2,3, Simone Marsili4

  • 1Computer-Aided Drug Design, In Silico Discovery, Therapeutics Discovery, Johnson & Johnson Innovative Medicine, Turnhoutseweg 30, Beerse 2340, Belgium.

Journal of chemical theory and computation
|March 4, 2026
PubMed
概括

对于药物发现至关重要的神秘口袋,来自复杂的蛋白质动态. 一种新的计算方法,SLICE,有助于探索这些动态,以确定新的药物标.

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Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques08:58

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Published on: July 5, 2018

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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