一种新型的多糖类血静剂,用于预防大结肠多切除后的手术后出血
Francesco Auriemma1, Gianluca Franchellucci2,3, Gianluca Andrisani4
1Gastrointestinal Endoscopy Unit, Humanitas - Mater Domini, Castellanza (VA), Italy.
Endoscopy international open
|March 4, 2026
概括
一种新型的止血粉在通过内镜粘膜切除 (EMR) 和内镜亚粘膜剖析 (ESD) 移除大结直肠病变后显著减少了手术后出血 (PPB). 这种植物性粉末为预防高风险患者出血并发症提供了一个有希望的解决方案.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 血液静止 血液静止 血液静止
背景情况:
- 术后出血 (PPB) 是内镜粘膜切除 (EMR) 和内镜亚粘膜切除 (ESD) 后的一个重大并发症.
- 有效的预防策略至关重要,特别是对于大结直肠病变.
- 研究了一种新型可再吸收的植物性静血粉末 (HaemoCer PLUS) 用于PPB预防.
研究的目的:
- 评估HaemoCer PLUS在预防大结直肠病变的EMR和ESD后PPB的疗效.
- 为了评估这种新型血液静止剂治疗的患者的延迟出血率.
主要方法:
- 在三个高等保健中心进行的前性试点研究 (2021年11月 - 2024年2月).
- 50名患有大结直肠病变的患者接受了EMR或ESD,随后进行了HaemoCer PLUS应用.
- 切除后没有使用内镜剪贴;HaemoCer PLUS被应用于整个切除后表面.
主要成果:
- 包括50名患者,平均病变直径为52.28毫米.
- 延迟出血发生在6%的病例中 (50名患者中有3人),术后30天以上没有出血报告.
- 单变量分析显示,PPB与病变大小,患者年龄或内镜切除技术之间没有显著的关联.
结论:
- 一种新型可再吸收的植物性静血粉末 (HaemoCer PLUS) 的应用似乎是减少EMR/ESD后延迟出血的有益方法.
- 这种方法对高风险患者群体和具有特定病变特征的患者可能特别有利.
- 需要进一步的研究,以在更大的队列中证实这些发现.
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