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Tuğçe Gezer Karabacak¹, Ahmet Kasım Kılıç¹, Hediye Pınar Günbey²

¹Department of Neurology, University of Health Sciences, Kartal Dr.Lutfi Kirdar City Hospital, Istanbul, Türkiye.

Noro psikiyatri arsivi

|March 4, 2026

概括

磁共振光谱 (MRS) 可以预测多发性硬化症 (MS) 的进展. 在MS患者中较低的thalamic myoinositol/creatinine比率表明疾病进展,有助于早期检测.

科学领域:

神经学神经学
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

多发性硬化症 (MS) 是年轻人残疾的主要原因.
监测疾病进展对于有效管理至关重要.
目前跟踪MS进展的方法包括临床评估和先进的成像技术.

研究的目的:

使用认知和物理参数监测多发性硬化症 (MS) 疾病进展.
评估光学连贯断层扫描 (OCT) 和磁共振光谱 (MRS) 在评估多发性硬化症进展中的实用性.
为了确定成像生物标志物来预测MS疾病的进展.

主要方法:

包括患有复发性复发性 (RRMS),继发性渐进性 (SPMS) 和初级渐进性 (PPMS) 形式的多发性硬化症患者.
使用的临床评估:扩展残疾状况尺度 (EDSS),九孔测试 (9 HPT),定时25英尺步行测试 (T25FWT) 和认知测试 (BICAMS,MoCA).
在基线和随访时进行了OCT和MRS检查,以与临床结果相关联.

主要成果:

与其他组相比,初级进展性多发性硬化症 (PPMS) 患者的残疾分数 (EDSS,9 HPT,T25FWT) 和认知分数 (MoCA) 较低.
视网膜神经纤维层 (RNFL) 的测量在RRMS患者中高于渐进性MS组.
使用MRS的较低基线 thalamic myoinositol/creatinine (mI/Cr) 比率 (<0.066) 显著预测了高灵敏度和特异性MS患者的疾病进展.

结论:

早期发现MS疾病进展对于及时干预至关重要.
像MRS这样的非侵入性成像技术可以作为有价值的预后工具.
来自MRS的thalamic mI/Cr比率是多发性硬化症疾病进展的显著,非侵入性预测指标.

关键词:

认知障碍认知障碍是一种认知障碍.在MR光谱检测中使用MR光谱.多发性硬化症多发性硬化症这就是Ocrelizumab.光学连贯性断层扫描 (OCT)这是一个渐进的过程.

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