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相关概念视频

High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...
Scanning Electron Microscopy01:07

Scanning Electron Microscopy

A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
Fundamental Principles
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Transmission Electron Microscopy01:15

Transmission Electron Microscopy

In 1931, physicist Ernst Ruska—building on the idea that magnetic fields can direct an electron beam just as lenses can direct a beam of light in an optical microscope—developed the first prototype of the electron microscope. This development led to the development of the field of electron microscopy. In the transmission electron microscope (TEM), electrons are produced by a hot tungsten element and accelerated by a potential difference in an electron gun, which gives them up to 400 keV in...
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Mesh Analysis01:20

Mesh Analysis

Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
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HERMES:一个开源的开源文献挖掘工具.

Julien Charest1, Katarina Priselac1, Georg H Reischer1

  • 1Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Wien 1060, Austria.

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概括

研究人员现在可以使用开源工具HERMES有效地找到和排序开放访问的生物医学文献. 这种文献挖掘软件为专业领域提供可定制的搜索标准和可复制的结果.

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科学领域:

  • 生物医学信息学 生物医学信息学
  • 计算生物学 计算生物学
  • 科学文献分析 科学文献分析

背景情况:

  • 开放式科学文献的快速扩张在识别相关出版物方面带来了挑战.
  • 当前的搜索引擎缺乏用户定义的排名,可重复性和特定领域的标准集成.
  • 专门的研究领域需要细微的方法来确定文献优先级.

研究的目的:

  • 推出HERMES,这是一个开源工具,用于针对性地检索和排序全文开放访问出版物.
  • 为研究人员提供透明,可定制和高效的文献发现方法.
  • 解决现有搜索引擎在专业科学领域的局限性.

主要方法:

  • 赫尔梅斯利用一个复合得分算法,整合关键字频率,引用数量和出版年龄.
  • 该工具支持诸如总结,生物医学实体识别和PDF报告生成等功能.
  • 一个直观的图形用户界面 (GUI) 和多线程处理方便复杂和大规模的文献挖掘.

主要成果:

  • 在PubMed Central (PMC) 中,HERMES可以对出版物进行有针对性的检索和排名.
  • 综合评分算法有效地根据用户定义的标准优先考虑相关文献.
  • 图形界面和高效的处理赋予研究人员权力,包括那些没有编程专业知识的人.

结论:

  • 赫尔默斯为科学文献发现提供了一个可复制和适应的框架.
  • 该工具提高了透明度,并促进了相关出版物的快速识别.
  • 赫尔梅斯促进社区驱动的扩展和定制,以满足各种研究需求.