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Updated: Jul 6, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

在肝细胞癌中,RPL28通过降低CDC6表达的调节来调节索拉芬尼抗性

Yi Shi1, Fangfang Chen1, Yuanyuan Weng1

  • 1Department of Molecular Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.

Frontiers in oncology
|March 4, 2026
PubMed
概括

核糖体蛋白L28 (RPL28) 通过上调CDC6.6来驱动肝细胞癌 (HCC) 中的索拉芬尼抗性. 向RPL28-CDC6通路可能会克服晚期HCC的耐药性.

关键词:
美国疾病预防控制中心6 CDC6 CDC6肝细胞癌是肝细胞癌.蛋白质组是蛋白质组的组成部分.核糖体蛋白质L28 (RPL28) 是一种索拉费尼布耐药性 索拉费尼布耐药性转录组 (transcriptome) 是一个转录组.

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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

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