推进获得CAR T细胞治疗的机会:来自社区瘤实践的见解和现实经验
Gary L Simmons1, Scott Cross1, Elias C Pittos2
1Virginia Oncology Associates, Norfolk, VA, United States.
Frontiers in oncology
|March 4, 2026
概括
社区瘤实践可以安全地为血液性恶性瘤提供门诊的仿真抗原受体 (CAR) T细胞疗法,扩大患者的获取. 这种方法表现出与学术中心相似的有效性,尽管需要改变政策来解决付款人的不情愿.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 化学抗原受体 (CAR) T细胞疗法为耐火性血液恶性瘤提供了持久的缓解.
- 目前的访问仅限于学术中心,在护理方面造成差异.
研究的目的:
- 评估在社区瘤实践中提供的门诊CAR T细胞治疗的安全性和有效性.
- 评估扩大在学术机构之外获得CAR T细胞治疗的可行性.
主要方法:
- 基于社区实践的门诊CAR T细胞治疗计划的回顾性审查.
- 六个月的结构化实施,以确保安全的门诊管理.
- 对接受各种CAR T细胞产品 (lysocel,ide-cel,axi-cel,brex-cel) 的患者进行监测.
主要成果:
- 41名成年患者接受了门诊CAR T细胞治疗.
- 细胞因子释放综合征 (CRS) 在68%,ICANS在22%;49%需要住院治疗,15%需要ICU护理.
- 100天和1年的缓解率与公布的数据一致; 4-1BB CAR T细胞显示较低的住院率.
结论:
- 门诊CAR T细胞疗法可以在社区瘤诊所安全地提供,扩大了获取范围.
- 基于社区的交付解决了地理障碍,但面临着付款人的不情愿.
- 政策改革是必要的,以促进基于社区的先进治疗.
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