乳酶上调影响非小细胞肺癌的病理变化,通过调节铁化
Yuxiu Wang1, Wenjing Xu1, Kaiqi Ren1
1Department of Respiratory and Critical Care Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
PeerJ
|March 4, 2026
概括
乳酸转移 (LTF) 的上调增强了非小细胞肺癌 (NSCLC) 的进展,通过抑制ferroptosis. 过度表达LTF促进癌细胞迁移和入侵,为NSCLC治疗提供了潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 铁,一种依赖于铁的细胞死亡途径,与癌症生物学有关.
- 乳酸转移 (LTF) 正在研究其在非小细胞肺癌 (NSCLC) 中的作用.
研究的目的:
- 调查乳酸转移 (LTF) 上调对NSCLC病理变化的影响.
- 确定LTF在抑制NSCLC中的铁化中的作用.
主要方法:
- 已建立的NSCLC细胞模型具有稳定的LTF淘汰或过度表达.
- 评估了细胞活力,迁移,入侵和上皮-介质细胞过渡 (EMT).
- 定量化的铁亡标志物 (MDA,GSH,Fe2+,ROS) 和关键调节蛋白 (GPX4,ACSL4).
- 在NSCLC患者的外周血液中分析了LTF表达.
主要成果:
- 在NSCLC中,LTF被上调,并增强了癌细胞迁移,入侵和EMT.
- 通过调节GPX4和ACSL4.4,LTF过度表达显著抑制了铁化.
- 在NSCLC患者的血液中检测到升高的LTF水平 (蛋白质和mRNA),与疾病阶段相关.
结论:
- LTF上调抑制铁亡,有助于NSCLC的进展.
- 通过调节铁灭,LTF代表了NSCLC的潜在治疗标.
- 周围血液中的LTF表达水平可以作为NSCLC的生物标志物.
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